|
rs1042169
|
HLA-DPA1;HLA-DPB1
|
Hepatitis B
|
|
0.710 |
GeneticVariation |
BEFREE |
Utilizing PCR sequencing, we verified the relationship of the top 3 most significant SNPs (rs1042169, rs9277355 and rs9277356) from the GWAS and genotypes of HLA-DPB1 with the HB vaccine response in Korean infants who received a scheduled vaccination.
|
31243853 |
2019 |
|
rs9277355
|
HLA-DPA1;HLA-DPB1
|
Hepatitis B
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, DPB1*04:02 possessing rs1042169 G - rs9277355 C - rs9277356 A is an independent predictor of the HB vaccine response in Koreans.
|
31243853 |
2019 |
|
rs9277356
|
HLA-DPA1;HLA-DPB1
|
Hepatitis B
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, DPB1*04:02 possessing rs1042169 G - rs9277355 C - rs9277356 A is an independent predictor of the HB vaccine response in Koreans.
|
31243853 |
2019 |
|
rs9277378
|
HLA-DPA1;HLA-DPB1
|
Leukemogenesis
|
|
0.010 |
GeneticVariation |
BEFREE |
Genome-wide association study reports strongest association of HLA-DPB1 rs9277378 with lymphomagenesis.
|
31187536 |
2019 |
|
rs111789468
|
HLA-DPA1
|
Childhood asthma
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
|
rs2021408
|
HLA-DPA1;HLA-DPB1
|
Oral Ulcer
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.
|
30837455 |
2019 |
|
rs2856821
|
HLA-DPA1;HLA-DPB1
|
Degenerative polyarthritis
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
|
30664745 |
2019 |
|
rs2856830
|
HLA-DPA1
|
Pulmonary arterial hypertension
|
C |
0.700 |
GeneticVariation |
GWASCAT |
A locus near SOX17 (rs10103692, odds ratio 1·80 [95% CI 1·55-2·08], p=5·13 × 10<sup>-15</sup>) and a second locus in HLA-DPA1 and HLA-DPB1 (collectively referred to as HLA-DPA1/DPB1 here; rs2856830, 1·56 [1·42-1·71], p=7·65 × 10<sup>-20</sup>) within the class II MHC region were associated with pulmonary arterial hypertension.
|
30527956 |
2019 |
|
rs2856830
|
HLA-DPA1
|
Associated Pulmonary Arterial Hypertension
|
|
0.010 |
GeneticVariation |
BEFREE |
A locus near SOX17 (rs10103692, odds ratio 1·80 [95% CI 1·55-2·08], p=5·13 × 10<sup>-15</sup>) and a second locus in HLA-DPA1 and HLA-DPB1 (collectively referred to as HLA-DPA1/DPB1 here; rs2856830, 1·56 [1·42-1·71], p=7·65 × 10<sup>-20</sup>) within the class II MHC region were associated with pulmonary arterial hypertension.
|
30527956 |
2019 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results demonstrated, for the first time, that expression of HLA-DPA1 alleles and rs3077 affected the risk of HBV infection.
|
30267609 |
2019 |
|
rs12722013
|
HLA-DPA1;HLA-DPB1
|
Blood Protein Measurement
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
rs3077
|
HLA-DPA1
|
IGA Glomerulonephritis
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first study demonstrating the significant associations of SNP rs3077, rs9277535 and rs7574865 and the haplotypes in the HLA gene with the risk of IgAN in a Southwest Chinese population.
|
29467950 |
2018 |
|
rs116722486
|
HLA-DPA1;HLA-DPB1
|
White Blood Cell Count procedure
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
Viral and host predictors of relapse were evaluated, including hepatitis B virus (HBV) surface antigen (HBsAg) level, anti-HBV core antibody level, and presence of single-nucleotide polymorphisms in the genes encoding the receptors NTCP (rs2296651) and CTLA4 (rs231775) and in the 3' untranslated regions of the genes encoding HLA-DPA1 (rs3077) and HLA-DPB1 (rs9277535); posttherapy predictors of relapse were also investigated.
|
29300980 |
2018 |
|
rs3097670
|
HLA-DPA1;HLA-DPB1
|
Allergic Reaction
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
|
29083406 |
2017 |
|
rs3077
|
HLA-DPA1
|
Occult chronic type B viral hepatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele in rs3077 was significantly correlated with OBI [odds ratio (OR) = 3.87, 95% confidence interval (CI) = 1.58-9.49, p = 0.0015].
|
29061159 |
2017 |
|
rs3135021
|
HLA-DPA1;HLA-DPB1
|
Occult chronic type B viral hepatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The combination of haplotype markers (TGA for rs3077-rs3135021-rs9277535) was associated with increased risk of OBI (OR = 4.90, 95%CI = 1.12-21.52 p = 0.038).
|
29061159 |
2017 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
|
28882445 |
2017 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B
|
|
0.900 |
GeneticVariation |
BEFREE |
No significant correlation was shown in HLA-DP rs3077 and rs9277535 with HBV infection or liver function recovery (P < .05).Our study concluded that HLA-DP (rs3077 and rs9277535) and HLA-DQ (rs7453920) were not significantly associated with HBV recurrence or HBV susceptibility, but HLA-DQ rs7453920 was related to prognosis of liver transplant recipients.
|
28640108 |
2017 |
|
rs9501251
|
HLA-DPA1;HLA-DPB1
|
Primary biliary cirrhosis
|
G |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis.
|
28425483 |
2017 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation |
BEFREE |
In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents.
|
28119119 |
2017 |
|
rs3077
|
HLA-DPA1
|
Vasculitis of the skin
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs3077 AA genotype carriers showed lower concentration of inflammatory cytokines and lower cutaneous vasculitis incidence than did the other two genotype.
|
28094303 |
2017 |
|
rs3077
|
HLA-DPA1
|
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, HLA-DP polymorphisms (rs3077 and rs9277535) were associated with SLE susceptibility and the levels of some inflammatory cytokines in SLE patients.
|
28094303 |
2017 |
|
rs3077
|
HLA-DPA1
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, HLA-DP polymorphisms (rs3077 and rs9277535) were associated with SLE susceptibility and the levels of some inflammatory cytokines in SLE patients.
|
28094303 |
2017 |